Eleanor Clarkson

• CDT Doctoral Researcher (Aligned) Supervisor: Dr Celine Cano
• Email: E.J.Clarkson2@newcastle.ac.uk
• Project Title: Small molecule tools to target glucose metabolism in non-alcoholic fatty liver disease

Institution: Newcastle University

Project Summary: This project aims to modulate glucokinase using small molecule tools to determine whether a reduction in hepatic glucokinase activity has the desired effect of halting the progression of non-alcoholic fatty liver disease. More specifically this project involves the design and synthesis of small molecule inhibitors that target glucokinase, from 3 chemical series validated by a high-throughput screening.